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Том 11 № 1 (2025)
Central Asian Research Journal for Interdisciplinary Studies (CARJIS) special issue – medicine sciences

Articles

THE INTERACTION OF LIVER MITOCHON- DRIAL MEGAPORES WITH POLYPHENOL COM- POUNDS RELATED TO THE PYRUVATE-MALATE SUBSTRATE

DOI 10.63294/afucon/vol11iss1/286 Google Scholar Google Scholar Страницы 578-582

Опубликован 2025-11-30

Авторы
Sayfieva X.Dj
Организация
Alfraganus University image/svg+xml
PDF (узбекский)

Аннотация

Ushbu tadqiqotda ba'zi polifenol birikmalarining kalamush jigar mitoxondriyalarida siklosporin (Cs-A) ga sezgir megaporlar funktsiyasiga ta'siri o'rganildi. Piruvat-malat substratlari va 10 mkM Ca²⁺ tomonidan qo'zg'atilgan mitoxondriyal megaporlardagi konformatsion o'zgarishlar tahlil qilindi. Natijalarga ko'ra, geksagidroksifenolil-1-(o-b-D-glyukopiranozid)-2-(o-4-D-galloyl-b-Dglyukopiranozid) 100 mkM konsentratsiyada nazoratga nisbatan megapor faolligini 70,5±4,8% ga inhibe qilgan. Bundan tashqari, geksagidroksifenol-1-(o-2-o-galloil-b-D-glukopiranozid)-1-(o-b-Dksilopiranozid) 100 mkM konsentratsiyada 72,5±2,9% inhibitiv ta'sir ko'rsatdi.

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