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Vol. 11 No. 1 (2025)
Central Asian Research Journal for Interdisciplinary Studies (CARJIS) special issue – medicine sciences

Articles

INTERRELATION BETWEEN INFLAMMA- TORY PERIODONTAL DISEASES AND FATTY LIVER DYSTROPHY: MODERN CONCEPTS AND PATHOGENETIC MECHANISMS

DOI 10.63294/afucon/vol11iss1/332 Google Scholar Google Scholar Pages 912-916

Published 2025-11-30

Authors
Malika H. Ibragimova a , Munira Sh. Ruzikulova b
Affiliations
a Tashkent State Medical University image/svg+xml
b Tashkent State Medical University image/svg+xml
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Abstract

The present review summarizes current knowledge about the relationship between inflammatory periodontal diseases (IPD) and fatty liver dystrophy (FLD). According to the World Health Organization (WHO), periodontal diseases remain one of the most common chronic inflammatory conditions affecting the quality of life through pain, bleeding, halitosis, and premature tooth loss. At the same time, fatty liver dystrophy, a nonalcoholic metabolic liver disorder characterized by excessive fat accumulation in hepatocytes, is increasingly recognized as part of systemic inflammatory and metabolic syndromes. This review discusses the mutual pathogenetic mechanisms linking periodontal inflammation and hepatic lipid metabolism disorders, highlighting the roles of oxidative stress, cytokine imbalance, immune dysregulation, and oral microbiota. Modern diagnostic approaches and therapeutic perspectives are also considered. The interrelation between oral and systemic health emphasizes the importance of an integrated approach to early diagnosis, prevention, and management of both conditions.

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