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Vol. 11 No. 1 (2025)
Central Asian Research Journal for Interdisciplinary Studies (CARJIS) special issue – medicine sciences

Articles

HOMILADORLAR JIGAR ICHI XOLESTAZI VA UNING AKUSHERLIK VA PERINATAL ASO- RATLARINI RIVOJLANISHDA OKSIDATIV

DOI 10.63294/afucon/vol11iss1/225 Google Scholar Google Scholar Pages 139-146

Published 2025-11-30

Authors
STRESSNING ROLI a , Husanova D.T b , Shavazi N.N c
Affiliations
a Samarkand State Medical Institute image/svg+xml
b Samarkand State Medical Institute image/svg+xml
c Samarkand State Medical Institute image/svg+xml
PDF (Uzbek)

Abstract

Samarqand Davlat Tibbiyot Universitetining 3-son akusherlik va ginekologiya kafedrasida Samarqand Shahar 1-son tug’ruq majmuasiga asoslangan kuzatuv tadqiqoti o'tkazildi. Axborotli rozilik olgandan so'ng tadqiqotga jami 100 nafar homiladorlar jigar ichi xolestazi tashhisi bilan homilador ayol kiritildi. Homiladorlar jigar ichi xolestazi bo'lgan 59 ayol va bo'lmagan 30 ayol tekshirildi. Homiladorlar jigar ichi xolestazi bo'lgan ayollar zardobida nitrit va nitrat ionlari va tiobarbiturat-reaktiv moddalarning umumiy kontsentratsiyasi aniqlandi va ularning onalik va perinatal asoratlarni bashorat qiluvchi prognostik ahamiyati tahlil qilindi. Batafsil tarix, jumladan, demografik ma'lumotlar, teri bilan bog'liq asosiy shikoyatlar, qichishish, terining shikastlanishi, homiladorlik davomiyligi bilan bog'liq boshlanishi, sariqlik, vaginal oqindi, o'tmishda yoki oilada shunga o'xshash lezyonlarning mavjudligi, kuchaytiruvchi omillar, tegishli tibbiy yoki teri kasalliklari va boshqalar aniqlandi va qayd etildi. Tashxisni tasdiqlash uchun tegishli tizimli tekshiruv va tegishli tekshiruvlar o'tkazildi. Homiladorlikning o'ziga xos kasalliklari bilan bog'liq qichishish tarixi bo'lgan barcha holatlarda jigar funktsiyasi testlari o'tkazildi. Turli darajadagi intrahepatik xolestaz (IHC) bo'lgan homilador ayollarda akusherlik va perinatal asoratlarning patogenezida oksidlovchi stressning rolini aniqlash. Oksidlovchi stress (P <0,0001) va endotelial disfunktsiyaning rivojlanishi (P (U) = 0,013) bilan birga keladi. IHD bilan og'rigan ayollarning qon zardobida tiobarbiturat-reaktiv moddalar (TBARS) kontsentratsiyasini aniqlash amniotik suyuqlikning mekonium bo'yalishini taxmin qilish imkonini beradi (TBARS> 17,64 mkmol/L, Se=75,0%, Sp=84,3%; AUC=0,820; 95,8;-95,9%; p=0,0007), simptomatik IHDda erta tug‘ilish (TBARS> 14,25 mkmol/L, Se=100,0%, Sp=71,4%; AUC=0,875; 95% CI 0,635-0,979; p=0,002) va bolalarda IHD sindromi bilan og‘rigan bemorlarning rivojlanishi. (TBARS> 17,32 mkmol/L, Se=71,4%, Sp=75,7%; AUC=0,774; 95% CI 0,648-0,873; p=0,005). Oksidlanish stressi VHD patogenezida va uning akusherlik va perinatal asoratlarida muhim omil hisoblanadi. Homilador ayollar homiladorlikning o'ziga xos dermatozlaridan tashqari ko'plab yondosh kasalliklarga moyil. Ushbu patologik holatlar faqat gravid holatiga xosdir. Batafsil tarix va klinik ko'rinishdan xabardor bo'lish tashxisni tasdiqlashga yordam beradi, ona va homila kasalliklarini kamaytirish uchun eng to'g'ri laboratoriya tekshiruvini o'tkazadi. Bundan tashqari, jigar faoliyatini monitoring qilish alohida e'tiborga loyiqdir.

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