MORPHOLOGICAL CHARACTERISTICS OF MYO- CARDIAL ANGIOGENESIS AND ITS IMPAIRMENT IN EXPERIMENTAL DIABETES
Abstract
Diabetes mellitus (DM) represents one of the most significant global health challenges, not only due to its metabolic derangements but also because of its strong association with cardiovascular diseases. Myocardial ischemia in the diabetic heart is accompanied by profound alterations in angiogenesis, impairing tissue perfusion and regenerative responses. Experimental models of diabetes, including chemical induction and genetic approaches, have provided important insights into the structural and molecular mechanisms underlying impaired myocardial angiogenesis. This article reviews the morphological and molecular features of myocardial angiogenesis in experimental diabetes, focusing on endothelial dysfunction, alterations in capillary density, ultrastructural damage, and dysregulation of signaling pathways such as VEGF, HIF-1α, and PI3K/Akt. Understanding these mechanisms is crucial for the development of novel therapeutic strategies to improve myocardial recovery in diabetic ischemic heart disease.References
- American Diabetes Association. Cardiovascular disease and diabetes: a scientific statement. Dia- betes Care. 2023
- Madonna R, De Caterina R. Cellular and molecular mechanisms of impaired angiogenesis in dia- betes. J Mol Cell Cardiol. 2022
- Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev. 2021
- Bugger H, Abel ED. Molecular mechanisms of diabetic cardiomyopathy. Diabetologia. 2020
- Carmeliet P, Jain RK. Angiogenesis in ischemia and diabetes. Nature Medicine. 2021
- Lenzen S. The mechanisms of alloxanand streptozotocin-induced diabetes. Diabetologia. 2020
- King AJ. The use of animal models in diabetes research. Br J Pharmacol. 2020
- Gao E, et al. A novel and efficient model of coronary artery ligation and myocardial infarction in mice. Circ Res. 2020
- Liu Y, et al. Histological changes in diabetic myocardium. Cardiovasc Pathol. 2022
- Zheng H, et al. Endothelial ultrastructural damage in diabetic ischemic heart disease. Ultrastruct Pathol. 2021
- Chou E, et al. Reduced VEGF expression in diabetic angiogenesis. Diabetes. 2022
- Li J, et al. PI3K/Akt signaling and diabetic angiogenesis. Front Cardiovasc Med. 2023
- Zhang L, et al. Inflammation and impaired angiogenesis in diabetes. Int J Mol Sci. 2021
- Rask-Madsen C, King GL. Endothelial dysfunction in diabetes. Lancet Diabetes Endocrinol. 2020
- Nakamura K, et al. Experimental angiogenic therapies in diabetic cardiomyopathy. Circulation Research. 2024
Downloads
Download data is not yet available.